Thermo Scientific™ HyPerforma™ Rocker Systems

The HyPerforma Rocker, Rock-IT BPC, and pH+DO2 sensor combine to provide next generation control and measurement for rocking bioreactor applications. The HyPerforma Rocker can be controlled by the HyPerforma G3Lab or G3Pro controllers using TruBio software. This turn-key package provides a complete solution for research, process development, or seed train production applications.


  • Compatible with most cell culture applications
  • Quick, simple set-up
  • Rock-IT BPCs embedded pH+DO2 sensor measures main critical process parameters
  • pH+DO2 sensor is USP Class VI and ADCF
  • pH+DO2 sensor design minimizes optical sensor drift
  • Plug-and-play with HyPerforma G3Lab bioreactor controllers
  • Powered by TruBio software
  • Standard service packages
  • cGMP capable

Optimize Cell Growth

Designed for R&D and cGMP scale-up, the HyPerforma™ Rocker allows the user to configure the rocking motion from a smooth waveform that minimizes shear force for sensitive cell lines to an aggressive motion that maximizes oxygen transfer for robust cells having high oxygen consumption. The transition from smooth to aggressive is controllable in 4 steps.

TruFluor Sensors

The HyPerforma Rock-IT BPC is a single-use rocker bag that's equipped with a pH+DO2 sensor comprising single-use sensors for dissolved oxygen, pH, and temperature. The pH+DO2 sensor leverages the technology behind TruFluor pH and DO in a compact assembly. The sensors are pre-calibrated and provide accurate, drift-free, in-situ measurements. The combined pH and DO optical reader uses advanced optical components including a large area photodiode that minimizes photo-degradation of the active pH and DO sensing elements. The pH+DO2 sensor also leverages the TruFluor temperature 316L stainless steel thermal window for highly stable readings.

pH+DO2 sensors are welded into single-use Rock-IT BPCs, eliminating the need for sterile connectors and their associated complications such as leakage and batch contamination. All wetted materials of the pH+DO2 sensor are USP class VI compliant and animal derived component free (ADCF). pH+DO2 sensors are identical to TruFluor pH and TruFluor DO sensors, allowing direct measurement comparisons and scale-up from 10 L rocker bags to 2,000 L stirred-tank, single-use bioreactors.

The TruFluor transmitters that are installed in the controller will automatically read the pH+DO2 sensor calibration and will allow one- and two-point calibrations as well as sensor health diagnostics and cable connectivity.

HyPerforma Rock-IT BPCs

A unique port-sensor assembly process allows the pH+DO2 sensor to be welded to the center at the bottom of the bag. The placement and design of the sensor enables all of the sensors to remain submerged in liquid even for small operating volumes. This results in a high degree of measurement fidelity for real-time process monitoring and control. HyPerforma Rockers can be used in cGMP settings instead of being confined to only cell amplification functions.

The HyPerforma Rock-IT BPC is available in three sizes: 10, 20, and 50 Liters. Each bag is delivered with all relevant certificates and conforms to USP Class VI standards. Rock-IT BPCs are available in a single, standard configuration for each volume. Please contact your sales representative if you require customizations for these bags.

Rock-IT BPCs are manufactured using multi-layer polyolefin-based, slip agent free film. This film provides superior extractables and leachables profiles, water vapor and oxygen barriers, and complete fluid integrity.

Rock-IT BPCs are sterilized using gamma radiation (25 to 40 kGy). Individual radiation indicators are affixed to each bag. Lot radiation information can be provided upon request. Each lot is tested for bacterial endotoxins. Lot release requires endotoxin levels below 0.125 EU/ml.

HyPerforma Rocker Trays

The tray that holds the Rock-IT BPC is designed so that the embedded pH+DO2 sensor's reader is mounted underneath the bag and will not disturb or encumber the rocking motion.

The HyPerforma Rocker's features make
starting your process quick and simple

Easy clip tray latches securely hold the BPC inside the tray, even when it is full and the rocker is set to the most aggressive motion setting.

The locking mechanism on the sensor's reader provides a repeatable and tight coupling between the reader and the pH+DO2 sensor.

These features are designed to support a quick set-up and to establish consistent contact between the bag and the tray for uniform heating and improved process temperature control.

Thermo Scientific™ HyPerforma™ Controllers

Choose the most appropriate controller for your specific needs. The HyPerforma G3Lab for benchtop and R&D use or the HyPerforma G3Pro for manufacturing are both fully plug-and-play with the HyPerforma Rocker and will auto-detect the rocker once it is connected to the controller.

HyPerforma Rocking Bioreactor

Dimensions (H x W x D) 264 x 782 x 701 mm (10.4 x 30.8 x 26.6 in)
Weight (Base + Tray) 38.5 kg (85 lbs)
Rocking Angle 2° to 12° Per Side
Rocking Rate 2 to 40 Cycles Per Minute
Working Volume (L) 5, 10, 25
Electrical Power

110 to 120 V/ 220 to 240 V, 50/60 Hz
Powered by G3 Lab Universal

Operating Temperature 0°C to 45°C (32° to 158°F)
Storage Temperature -40°C to 70 °C / -40°F to 158°F
Humidity <95%, non-condensing
Acoustic Noise Level <70 dB A
pH sensor range (pH units) 5.5 to 8.5
pH sensor relative accuracy ±0.05 pH over calibration range after a 2-point calibration having 0.3 to 0.8 pH units of separation
DO sensor range (%Sat) 0% to 250%
DO sensor limit of detection 0.03% O2
Accuracy @25 °C: <±1% at 20.95% O2
Temperature 10°C to 45°C (50° to 113°F)
Temperature accuracy ±0.15°C @ 15°C to 40°C (±0.25°F @ 59° to 104°F)
Precision ±0.1°C (±0.2°F)

HyPerforma G3Lab Controller


Utility Tower (H x W x D) 438.4 x 250 x 482.6 mm (17.3 x 9.5 x 19 in)
Tower Rating NEMA 2
Operating Temperature 5ºC to 40ºC (41ºF to 113ºF)
Storage Temperature -40ºC to 70ºC (-40ºF to 158ºF)
Relative Humidity 5% to 95% (non-condensing)
Certifications Verified to meet CE standards EN-60101 and EN-61325
Weight / Shipping Weight 14 kg / 21.4 kg (31 lb / 47 lb)


Agitation • SmartMotor Controller – Glass Vessel or Rocker
• Vessel Adapter Box Connection – Thermo Scientific
   HyPerforma™ SUB only
• Serial Port Connection to GE Wave™ Rocker – EHT
   Model only
pH (Up to 2 inputs) TruSens Transmitter (electrochemical sensors ) or TruFluor® pH Transmitter (Rocker, Single-Use Vessel)
Dissolved Oxygen (DO) (Up to 2 inputs) TruSens Transmitter (Electrochemical Sensors ) or TruFluor® DO Transmitter (Rocker, Single-Use Vessel)
Temperature TruSens Transmitter (RTD) or TruFluor® (rocker)
Foam Level Conductivity Input
Liquid Control Four (4) Variable-Speed Peristaltic SmartPumps, Watson Marlow® Series 114 
Cold Finger Solenoid Digital Solenoid Valve
Gas Control

Standard: Four (4) MFCs with Two (2) Output Connectors

Optional: Six (6) MFCs with Three (3) Output Connectors

Scales / Load Cells Analog Input Via Scale Port
Auxiliary Seven (7) Analog Inputs and Four (4) Analog Control Loops
Digital Input Two (2) 24V DC
Digital Output Two (2) Dry-Relay Contacts

Hardware / Peripherals

Thermal Control Heater Blanket, Chilled Water Source
External Pumps Two (2) Watson Marlow® Pumps on a Finesse Pump Tower

Cable Types

pH K8, VP, TruFluor®
DO D4, VP6, VP8, TruFluor®
Heater IEC-5-15 Receptacle

Glass: 1L to 20L

Single-Use (SUB): 2.4L to 45L

Rocker: 10L to 50L

TruBio Software

Unify upstream process trains with user-friendly, configurable, scalable
bio-process software.

SmartRocker Systems

Configurable rocker motion combined with the unique SmartPuck to revolutionize rocked cell culture.